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王珠银(教授)

【来源:bet365提现要多久 | 发布日期:2017-09-19 】     【选择字号:
 
姓 名
王珠银
所属部门

功能有机分子国家重点实验室

化学院高通量药物筛选中心
职 称
教授
导师类别
研究方向
核酸和蛋白质的合成生物学
联系方式

Tel: 0931-8912263 Email: zywang@lzu.edu.cn

    王珠银,博士,教授,2012年中组部第八批千人计划获得者。1987年及1990年先后获得兰州大学化学系有机合成专业学士和硕士学位,1998年获得美国新泽西州立大学即罗格斯大学Rutgers University)生物化学和分子生物学专业博士学位,19981999年在纽约哥伦比亚大学从事博士后研究。19992004年,在美国PharmaSeqInc.公司任首席科学家,从事基因芯片研究;20042013年在美国金斯瑞公司(GenScript Inc.)从事研发工作,历任蛋白部门总监,新技术研发部总监,获美国GenScript公司成就奖,2013年受美国GenScript公司委派,在南京金斯瑞生物科技有限公司任副总裁,并兼任新技术研发部总监。2014年受聘于河海大学力学与材料学院, 2017年被bet365提现要多久以人才引进聘为教授。

    研究方向:王珠银教授主要承担兰州大学化学院高通量药物筛选平台建设和管理工作。研究方向为核酸和蛋白质的合成生物学,所研发或参与研发的多项技术处于全球领先地位,公开发表论文17篇,申请美国和中国专利50多项。

联系方式: Tel: 0931-8912263      Email: zywang@lzu.edu.cn

教育背景:

博士后:      1998.7 – 1999.10,纽约哥伦比亚大学,病理学系。

博士:           1993.8 – 1998.6  新泽西州立大学,生物化学与分子生物学专业。

硕士:           1987.9 – 1990.7  兰州大学,有机合成专业。

本科:           1982.7 – 1987.7  兰州大学,化学系。

荣誉和奖励:

入选中组部第八批千人计划2012年。

入选江苏省双创计划2011年。

荣获美国 GenScript公司颁发的创新奖2009年。

荣获美国新泽西州立大学Stanley Mandeles 研究奖1997年。

发表论文:

1) Ji Li, Zhuying Wang, Ignacy Gryczynski, Wlodek Mandecki (2010), Silver nanoparticle-enhanced fluorescence in microtransponder-based immuno- and DNA hybridization assays. Analytical and Bioanalytical Chemistry, 398(5):1993-2001.

2) X. Lin, J.A. Flint, M. Azaro, T. Coradetti, W.M. Kopacka, D.L. Streck, Zhuying Wang, J. Dermody, W. Mandecki (2007), Microtransponder-based multiplex assay for genotyping cystic fibrosis, Clin.Chem. 53:1372-1376.

3) W. Mandecki, B. Ardelt, T. Coradetti, H. Davidowitz, J.A. AFlint, Z. Huang, W.M. MKopacka, X. Lin, Zhuying Wang, Z. Darzynkiewicz (2006), Microtransponders, the miniature RFID electronic chips, as platforms for cell growth in cytotoxicity assays, Cytometry A. 69:1097-1105.

4) Zhuying Wang, G Trillo-Pazos, SY Kim, M Canki, S Morgello, LR Sharer, HA Gelbard, ZZ Su, Dc Kang, AI Brooks, PB Fisher and DJ Volsky (2004), Effects of  human immunodeficiency virus type 1 on astrocyte gene expression and function: Potential role in neuropathogenesis. J. of  NeuroVirology, 10 (Suppl.1):1-8.

5) Zhuying Wang, O Pekarskaya, M Bencheikh, W Chao, HA Gelbard, A Ghorpade, JD Rothstein, and DJ Volsky (2003), Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp 120. Virology, 312(1):60-73.

6) Wlodeck Mandecki, Michael G. Pappas, Natan Kogan, Zhuying Wang, and Beata Zamlynny (2002), Light-Powered Microtransponders for High Multiplex-Level Analysis of Nucleic Acids. Chapter 4 in: Microfabricated Sensors: Application of Optical Technology for DNA Analysis. ACS Symposium Series 815, American Chemical Society ? 2002; pp. 57-69.

7) Zhuying Wang, Kavita Shah and Tariq M. Rana (2001), Probing Tat Peptide-TAR Interactions by Psoralen Photo-Cross-Linking. Biochemistry, 40:6458-6464.

8) Michael G. Pappas, Zhuying Wang, et al (2000), Light-Powered Microchips for Diagnostics, Genomics and Drug Discovery. Luminescence Forum 6 (3), 4.

9) Zhuying Wang and Tariq M. Rana (1999), Probing RNA-Protein Interaction by Psoralen photocrosslinking. Methods  Mol. Biol., Vol. 118:49-62.

10) Zhuying Wang and Tariq M. Rana (1999), Proximity of a Tat peptide to the HIV-1 TAR RNA loop region determined by Site-Specific Photo-Cross-linking. Bioconjugate Chemistry, 10:512-519.

11) Zhuying Wang and Tariq M. Rana (1998), RNA-Protein Interactions in the Tat-TAR Complex Determined by Site-Specific Photocrosslinking. Biochemistry, 37:4235-4243.

12) Zhuying Wang and Tariq M. Rana (1997), DNA Damage-Dependent Transcriptional Arrest and Termination of RNA Polymerase II Elongation Complexes in DNA Template Containing HIV-1 Promoter. Proc. Natl. Acad. Sci. USA, 94:6688-6693.

13) Zhuying Wang and Tariq M. Rana (1996), RNA Conformation in Tat-TAR Complex  Determined by Site-Specific Photocrosslinking. Biochemistry, 35:6491-6499.

14) Zhuying Wang and Tariq M. Rana (1996), Protein Orientation in Tat-TAR Complex Determined by Psoralen Photocrosslinking. J. Biol. Chem., 271:16995-16998.

15) Yiping Liu, Zhuying Wang and Tariq M. Rana (1996), Visualizing A Specific Contact in the HIV-1 Tat Protein Fragment and TAR RNA Complex by Photocrosslinking. J. Biol. Chem, 271:10391-10396.

16) Shah, K., Neenhold, H., Zhuying Wang  and Tariq M. Rana (1996), Incorporation of an Artificial Protease and Nuclease at the HIV-1 Tat Binding Site of TAR RNA. Bioconjugate Chemistry, 7:283-289.

17) Zhuying Wang,  Kavita Shah and Tariq M. Rana (1995), Chemical Conversion of a TAR RNA-Binding    Fragment of HIV-1 Tat Protein into a Site-Specific Crosslinking Agent. J. Amer. Chem. Soc.,117:5438-5444.

已获授权美国专利:

9,061,236     Gel electrophoresis device for loading large sample; 8,968,541      Rapid electrophoresis binding method and related kits; 8,815,600      Homologous recombination-based DNA cloning ...; 8,785,352      Metal nanoparticle structures for enhancing ...; 8,603,780   Methods and compositions for enhanced expression; 8,501,454       Homologous recombination-based DNA cloning;  8,334,103      Composition Related to Rapid ELISA Process, 8,326,547     Method of Sequence Optimization; 7,824,867    Rapid ELISA processes and related compositions; 7,816,092     Rapid C-ELISA process and related compositions; 7,279,280       Apparatus and method for detecting genetic mutations.

已获授权中国专利:

201010220009.5 生物聚合物快速染色法;201020694719.7      一种用于蛋白质快速染色转印的仪器;201030682259.1 蛋白质快速染色转印仪器;201120114698.1   新型磁力混合设备;201220019160.7       半自动多肽合成仪;200980143524.3     基于同源重组DNA的克隆方法及组合物;201220336981.3   一种固体表面液体保留装置。